MiMedx AMNIOFIX® and AMNIOCORD® are both human placental tissue allografts used as protective barriers in surgical settings, but they are not the same product.
The biggest difference is the tissue source.
AMNIOFIX is made from dehydrated human amnion/chorion membrane, while AMNIOCORD is made from dehydrated human umbilical cord tissue. Those different tissue sources create different thickness, handling, and surgical-use characteristics. MiMedx describes AMNIOFIX as a thinner membrane product, while AMNIOCORD has a thicker extracellular-matrix profile that can be useful in deeper surgical sites or when graft fixation is desired. MIMEDX
What Is MiMedx AMNIOFIX?
AMNIOFIX is a dehydrated human amnion/chorion membrane allograft, commonly abbreviated DHACM.
MiMedx describes AMNIOFIX as a protective barrier used on surgical wounds and exposed tissue. It is available in sheet and fenestrated configurations and in multiple sizes.
The product is processed using MiMedx’s proprietary PURION® process and is terminally sterilized for an additional level of safety. MiMedx also states that the PURION process preserves extracellular-matrix components, including 300+ regulatory proteins. MIMEDX
What Is MiMedx AMNIOCORD?
AMNIOCORD is a dehydrated human umbilical cord allograft.
Unlike AMNIOFIX, which is derived from amnion and chorion membrane, AMNIOCORD is derived from umbilical cord tissue and provides a thicker extracellular-matrix structure containing hyaluronic acid and collagen.
MiMedx describes AMNIOCORD as useful in smaller or deeper surgical sites, for tendon, bone, or hardware coverage, and in situations where graft fixation may be desired. Its thickness allows the graft to be sutured when needed. MIMEDX
AMNIOFIX vs. AMNIOCORD at a Glance
The key differences are:
AMNIOFIX
Dehydrated human amnion/chorion membrane
Thinner membrane profile
Sheet and fenestrated configurations
Available in multiple sizes
Used as a protective barrier across a broad range of surgical wounds
PURION processing preserves 300+ regulatory proteins
Terminally sterilized
AMNIOCORD
Dehydrated human umbilical cord allograft
Thicker extracellular-matrix profile
Contains hyaluronic acid and collagen
Useful in smaller or deeper surgical sites
Can be sutured when fixation is desired
PURION processing preserves 250+ regulatory proteins
Terminally sterilized
Both products are human-derived placental tissue allografts, but their physical characteristics make them useful in different surgical situations. MIMEDX
Why Thickness Matters
The physical profile of the graft can affect how a surgeon handles and positions it.
AMNIOFIX has a thinner membrane profile that can conform easily to tissue surfaces.
AMNIOCORD is thicker and more substantial, which MiMedx specifically highlights for deeper surgical sites, tendon or bone coverage, hardware coverage, and situations where suturing or fixation may be useful. MIMEDX
That does not mean one product is universally better than the other.
The more useful question is:
Which product configuration best fits the surgical site and the surgeon’s objective?
How Are AMNIOFIX and AMNIOCORD Similar?
Despite their differences, the two products share several characteristics.
Both are:
Human-derived placental tissue allografts
Processed using MiMedx’s PURION technology
Terminally sterilized
Shelf stable
Used as protective barriers in surgical environments
Part of MiMedx’s broader surgical biologics portfolio
MiMedx lists both AMNIOFIX and AMNIOCORD across several surgical specialties, including orthopedic surgery, plastic surgery, vascular surgery, colorectal and general surgery, and gynecologic surgery. MIMEDX
Which Product Might Fit Which Surgical Situation?
At a high level, AMNIOFIX may be attractive when the surgeon wants a thinner, flexible membrane-style graft.
AMNIOCORD may be attractive when the surgeon wants greater thickness, deeper placement, coverage over tendon, bone, or hardware, or the ability to secure the graft with sutures.
The decision should always be based on:
The surgical anatomy
The size and depth of the site
Desired graft thickness
Handling characteristics
Need for fixation
Current product labeling
Instructions for Use
Available clinical evidence
AMNIOFIX and AMNIOCORD Are Complementary Products
This is the most important takeaway.
AMNIOFIX and AMNIOCORD are not simply two versions of the same graft.
They are different tissue technologies within the same MiMedx surgical biologics portfolio.
AMNIOFIX provides a thinner amnion/chorion membrane configuration.
AMNIOCORD provides a thicker umbilical-cord extracellular-matrix configuration.
That gives surgeons different options depending on the surgical environment.
About 6|Sixty Biologics
6|Sixty Biologics is an independent surgical biologics distributor focused on helping surgeons and healthcare organizations understand and access advanced biologic technologies.
6|Sixty works with MiMedx surgical biologics, including AMNIOFIX and AMNIOCORD, across multiple surgical specialties.
Our goal is to help clinicians, hospitals, and industry professionals better understand how different placental tissue allografts fit within modern surgical care.
References and Additional Information
MiMedx — AMNIOFIX
Official manufacturer information regarding AMNIOFIX composition, processing, configurations, and surgical-use examples.
MiMedx — AMNIOCORD
Official manufacturer information regarding AMNIOCORD composition, processing, thickness, handling, and surgical-use examples.
Important Information
This article is provided for educational purposes only and is not medical advice.
Product selection and use should be determined by qualified healthcare professionals after reviewing current manufacturer labeling, Instructions for Use, institutional requirements, patient-specific circumstances, and available clinical evidence.
6|Sixty Biologics is an independent distributor and is not MiMedx. AMNIOFIX®, AMNIOCORD®, PURION®, and MiMedx are trademarks or trade names of MiMedx Group, Inc.
